P-HIPSTer contains predicted viral-host PPIs for 15 human-infecting coronaviruses. 3TrophoSYS GmbH, Botzstrasse 5, 07743 Jena. If you wish to start a PhD at the University of Jena you have to register in the portal with your personal data. Please also have a look at our general list of virus bioinformatics tools. The information provided is for research only and we cannot guarantee the correctness of the data. This tool is a work in progress and any suggestions would be greatly appreciated. DisGeNET is a discovery platform containing one of the largest publicly available collections of genes and variants associated with human diseases. I look forward to meeting you – online and in person. International Organizations and Crisis Management - IOCM in short - is the masters degree in political science of the Chair for International Relations at the Friedrich-Schiller-University Jena. For the third year Bachelor Biology course “Vom Molekül zu komplexen Gemeinschaften (BB3.Ö13)“ at FSU Jena, PhD student Jennifer Gabriel and research group leader Nicole van Dam, Molecular Interaction Ecology designed a Corona proof “brown bag” practicum. P-HIPSTer employs structural information to predict pan viral-human PPIs. A research team from the Chair of Economic Geography at the University of Jena has been examining the severity of the consequences. The new search uses nhmmer and enables the users to explore the results using facets powered by the EBI Search. Corona cannot fail but impact our classes, as it has impacted our lives. [�{�I�)�$ ʚ3;tA!paTB�>XZL���z��P� ]� ��T�ˀ�Š{���� �6ׂcPYp�C �ǘ���Ys4*8��d�¦��B�֚S�1ơĴ��3`���TCDy�U^@�:�Y�x�ЁZ�����h�ᅌ0�yf���I��v�l���7��t�O��ȌJ�����W��q�i\� "�ʈ_'��DQ�@C�D��sbC���|��Sj�W`ƀC�Z*�E��w̚r�� "Bc‹�.��K��'�(hF�Eޔ���Fk��5����AGg�ӷ!Fiz��ʺ�Ԇ{�k���i�8 �oSS|\�@� �A�i�\�C�nh�D��Ê�\�I=���= 2m|��P������u�ɍ����mp+25�yR*�$?%T�gX�;ɲ>Snʖ&�k�V��o:yY�I�m��l��i+k wo�k���ך@M��5��Si� 0׬n���t��.u��xԥP�szi dr+���e��o2SV�$�&5b�0��b�[��*�^C�3~���h`R��/��� �;�D>��_���+��Y7�C=���;��� �u�mXr���ң�*��h�\�&�$�LݰҶf�c�˱k+譱l��|?�~�dS� Predicted proteins encoded by the sequence are validated with nucleotide-to-protein alignments using BLAST. Nextstrain is an open-source project to harness the scientific and public health potential of pathogen genome data. COPASI is a software application for simulation and analysis of biochemical networks and their dynamics. You can search the comprehensive database for sequences & strains, immune epitopes, 3D protein structures, host factor data, antiviral drugs, plasmid data. In Thuringia, the first corona cases occurred at the beginning of March, and in mid-March the first infections were also confirmed in Jena. UniProt also hosted webinars to describe the portal and publication submission system. 07743 Jena. The pipeline is designed for reproducibility and scalability in order to ensure reliable and fast data analysis of SARS-CoV2 data. BEAST 2 includes a graphical user-interface for setting up standard analyses and a suit of programs for analysing the results. The tool allows users to highlight and prioritize the most frequent mutations in specific protein regions, and to monitor their frequency in the population over time. p�$F�l�m����A U��t��S?��)��ͻZ�ݺc�������3�{ϥSGR�. the discovery of potential drug targets and development of therapeutic strategies. This heavy usage might lead to bottlenecks when it comes to setting up new meetings, or to disruptions when starting meetings. the routine detection of SARS-CoV-2 infection. The Data Portal brings together and continuously updates the relevant COVID-19 datasets and tools. For example, it is possible to search for a fragment of a SARS-CoV-2 genome, select similar sequences identified in COVID-19 patients, and browse sequence variants from different countries. The model includes a basic pharmacodynamic response (to assembled virions) to cause cell apoptosis. H���C�bTB���I1�\�Œ��g��v�H��[6v3y�-���� �2m�B��kħ��3�0ϸ��q�q�ʘ�n�Oڸ������-2ѸMΰ'Аr�|9�J���딶�k7��S���z�T�:ǔ���.e�B�+�j��9� ��]����׻�7UZBݮ�3�����X5����� ����,���ϻ��9uļ�����]o�؂�#>5)p��6�������y���r����l�C��n���������?�����l?t7t���]��$k�}W8x��sS���6Ѻߦ���m¡ߖX5n�>]l�@�)�˟6J��'". Repurpose drugs. The viral sequences are regularly extracted from the NCBI BLAST database and the metadata is retrieved from the associated INSDC entries. the reliable analysis of sequencing data. Thuringia’s economy has been hit hard by the corona pandemic, plunging the state into a deep recession. Handlungsempfehlungen an Lehrende und Prüfungsämter kommuniziert, auf die sich Studierende berufen können. We cover workflows and tools for. Its main focus is set on drug interactions either addressing viral proteins or human proteins that could be used to treat COVID. The corona pandemic is a global threat and major challenge for numerous countries. Medizin-Studierende oder Personen mit medizinischer Vorbildung, die sich engagieren möchten, können sich an Karsten Krohn vom Universitätsklinikum Jena Krohn@med.uni-jena.de wenden. ��K���އ�������% Appropriate PCR primer pairs for DNA metabarcoding would match to a broad evolutionary range of taxa, such that we only need a few to achieve high taxonomic coverage. ��-�X+�rO��4��L`-�K���L��Z2( �}���`�d���W�~Lp"��th�z�'�4����ǂ@$��r��7j�L�^3�(�"�9�=����h� �;%� �BI�$*�9.�XF�Ordք� �����! /� ��lJ�4��s����2�����7���a)h��D�u��s�f�N?�}=��B��t2c}��'@ҟ�@Ճ_/�������h��d��ejΘ��+��!T��;�)a�������7S��̉*-����p��/!�`����к/�fȋ�����/` �+������0��4�.^Ã��`#�k��r4ܣ��ǐ�U/pC��={���� {C��hQ9OL�ˮx>�~�*�+���O!��Q}$��~�����1T)�5Q���/.�0��[���zi��\'��y ��X��C���]w�z.v�޻.x��4،�ӓ~Ķ���!a���A�7��{�I�V�4����7�|j-�j%>��_����9*{odj��ğ�r�Y�M�-�1(d���:���U/���a(���׈u��Үp���%f�w����GO��t�Tثd���àR{�L7�|Ap�j,�d)i ËtV��c2�q�I���q]��d�9�G$y%���Z��A�É�f�p�S�q�'�}��alה�1��C�=���@q/&c��T8�ɑ�G�M/�C�/ͩ��I&��՝������hb�E�R�ތ�!T@��D*�r��\�:��'&�E /�٧�o�K��$ƒ�G�ͣ�M�q�����KO'\3��_����5g�,�dT�[j��y����< �*�y+9�%���Қs�e���s0���0�&(��/����3�M��8�(��:U:OLp�u�lad�q���0g6�M}��˭�q�����v�=|� �/��77�$ The Pfam profile hidden Markov model (HMM) library in combination with the HMMER software facilitates rapid search and annotation of coronaviruses and can be used to generate multiple sequence alignments that allow the identification of mutations and clusters of related sequences, particularly useful for outbreak tracking and studying the evolution of Coronaviruses. Informieren Sie bitte auch das Internationale Büro der Universität Jena: international@uni-jena.de Henceforth, it is possible to proceed the studies or to start the studies without being physically in Jena. the tracking of the COVID-19 pandemic and evaluation of containment measures. The ELM server includes an online tool for the identification of motifs in user input sequences, using context filters (based on structural information, localization, sequence complexity and conservation) to refine results. It can be used as a method of reconstructing phylogenies but is also a framework for testing evolutionary hypotheses without conditioning on a single tree topology. First Act. With sadness, we regret to inform you that we have to cancel our 7 th pairfam international interdisciplinary conference on "Personality and relationships across the life span in Jena", July 2-3 2020, due to the evolving corona virus situation. Last update: June 2, 2020 Due to the Corona pandemic, the courses in the current summer term 2020 and also in the upcoming winter term 2020/2021 will be online courses. Sequence data are essential to design and evaluate diagnostic tests, to track and trace the ongoing outbreak, and to identify potential intervention options. International organizations take action in order to prevent a further spread of the virus—with the World Health Organization (WHO) leading the … This applies initially until the start of the summer semester lecture period on 4 … We are happy to answer your enquiries via our contact form. �dj��N�cswdQ�.^�)�2 Y3 kRrT�U�,a��f&�$��ɬ���䭪c�� "��";2�]���"���]���'- The European COVID-19 Data Portal was launched by EMBL-EBI in conjunction with the European Commission, the European Open Science Cloud and ELIXIR, as part of the wider European COVID-19 Data Platform. The nationwide survey "Studying in Germany in Corona Times" aims to examine the effects of the crisis on students at German universities and to shed light on the special features, challenges and opportunities of the largely digital summer semester 2020. BEAST 2 uses Markov chain Monte Carlo (MCMC) to average over tree space, so that each tree is weighted proportional to its posterior probability. ViralZone project is handled by the virus program of SwissProt group. Im Krankheitsfall/wenn Symptome auftreten: wenn Sie in Jena wohnen, müssen Sie die Corona-Hotline +49 3641 492222 und das Fiebertelefon +49 3641 493333 informieren (alternativ: corona@jena.de). Schools and daycare centres in Thuringia closed from 17 March. The European COVID-19 Data Portal was launched by EMBL-EBI in conjunction with the European Commission, the European Open Science Cloud and ELIXIR, as part of the wider European COVID-19 Data Platform. Encountering Covid-19: Jamais vu or Déjà vu? Physik): Course takes place: Yes: Multimedia support: PDF (lecture slides), Video for the PDF (explanations of slides) Interaction: video conference, Discussion and feedback via discussion boards in Moodle (every week) This way users can get a fully annotated report on candidate disordered interaction sites, highlighting their relationships with Pfam domains, for any protein of interest. 5Institute for Medical Microbiology, University Hospital Jena, Am Klinikum 1, 07747 Jena. CoVex is a unique online network and systems medicine platform for data analysis that integrates virus-human interactions for SARS-CoV-2 and SARS-CoV-1. r�F�32� 9W Apoptosed cells release some or all of their internal contents, notably including virions. On average the observed changes would be expected to have no or minimal consequence on virus biology. Die Browser-basierte Lösun And our most important services will continue: We are processing all incoming applications including your mail. The ViPR database integrates various types of data for multiple virus families. SARS-CoV-2 release is coming (May, 1st). Pufferlösungen für PCR-Tests We are curating a list of bioinformatics tools designed explicitly for SARS-CoV-2 and coronaviruses. You can find more information at: iocm.uni-jena.de. Matthias C. Kettemann Es werden keine Daten im Hintergrund erhoben, jeder Scan-Vorgang ist für den Nutzer vollständig nachvollziehbar. Dezember 2020 . Mai, findet der Hochschulinformationstag (HIT) der Universität Jena erstmals digital statt. Letzter Stand: 16. Each virus or family page gives an easy access to UniProtKB/Swiss-Prot viral protein entries. PriSeT has been applied to 19 SARS-CoV-2 genomes and computed 114 new primer pairs with the additional constraint that the sequences have no co-occurrences in other taxa. Indeed, this tree has never borne so much fruit, and so superb. � �]{s�F��ۮ�w���Yr�|ʒE�ϖ��[��=)��Km��� ��3R��~���A"H�q��� ������|�7ή���̵�>q��;���j����3�w�k6�pay��9�˥J�;��^��bԆ��4�:貏!_�;��5�uW�T�ݸ�٭���5�R1=���m�E'��S$�LY���/�4eS*~�VK!m�IY)�BW���n�΄�eY!��� F���y�`H���ã�r �-!u�h�m0���b]s�p�kNݮ�����N�)�������|���xw>>��T�vɇ�/���vO��RL�ո#�cW���O�ݩ.��`e��*}�~�.� �sen��M�$W\���O���5�=΄��=[��(�8Z�)�wG�P���hKu��/��B���{�|ڳY�2���wKt�=�ܻ����T|�1��>��w\��]Z Explore the virus-host interactome. When I called him to say thank you, he calmly said: “Ah, that’s the radiation. It estimates rooted, time-measured phylogenies using strict or relaxed molecular clock models. In the autumn of 1986, I got a box of apples from my uncle. CoV-GLUE is an online web application for the interpretation and analysis of SARS-CoV-2 virus genome sequences, with a focus on amino acid sequence variation. Service hours of the hotline: daily 10:00 - 14:00. Public life had largely come to a standstill. Increase of test capacities for suspected corona cases Researchers at the Friedrich Schiller University of Jena and the University Hospital Jena find an alternative to scarce buffer solutions when testing for the novel corona virus. Find putative drug targets. The virus is uncoated to explose viral RNA, which synthesizes viral proteins that are assembled into a virion. The goal is to aid epidemiological understanding and improve outbreak response. The GISAID Initiative promotes the rapid sharing of data from the coronavirus causing COVID-19. It implements different network-based approaches for the identification of new drug targets and new repurposable drugs. 4Institute for Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena. VirHostNet is a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks. Internalized ACE2 receptors release their virus cargo and are recycled back to the surface. COVID-19 UniProt portal provides early pre-release access to (i) SARS-CoV-2 annotated protein sequences, (ii) closest SARS proteins from SARS 2003, (iii) human proteins relevant to the biology of viral infection, like receptors and enzymes, (iv) ProtVista visualisation of sequence features for each protein, (v) links to sequence analysis tools, (vi) access to collated community-contributed publications relevant to COVID-19, as well as (vii) links to relevant resources. Corona virus: Availability and Restrictions at Graduate Academy. Among them is the ACP auditorium, where main lectures in the M.Sc. The Friedrich Schiller University Jena has equipped several lecture halls to provide live streaming of lectures and seminars. information on gene functions from Gene Ontology, Support for facets and keyword searches for exploring results, Explore up to 1,000 top hits (compared to 100 in BLAST), Integration with Rfam to annotate structured RNA elements. DisGeNET COVID-19 data collection shows the results of applying text mining tools to the LitCovid dataset, to identify mentions of diseases, signs and symptoms. It is capable of processing large libraries and is robust against mislabeled or low quality references.